Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1971
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not assignable; Insufficient detail in the IUCLID entry to determine reliability.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Enzymatic Dechlorination: Dechlorination of Chloroethanes and Propanes in vitro
- Author:
- van Dyke, R.A., Wineman, C.G.
- Year:
- 1 971
- Bibliographic source:
- Biochem. Pharmacol. 20, 463 - 470
Materials and methods
- Type of study / information:
- Type: other: Biotransformation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- - Name of test material (as cited in study report): 1,2-Dichloropropane
Constituent 1
Results and discussion
Any other information on results incl. tables
Analysis with rat liver microsomes showed that the enzyme responsible for the dechlorination of 1,2-dichloropropane needs O2 and NADPH. Pheno-
barbital and benzpyrene can inducethis enzyme but not methylcholanthrene
Applicant's summary and conclusion
- Conclusions:
- Analysis with rat liver microsomes showed that the enzyme responsible for the dechlorination of 1,2-dichloropropane needs O2 and NADPH. Phenobarbital and benzpyrene can induce this enzyme but not methylcholanthrene.
- Executive summary:
The enzymatic dechlorination of a series of chloroethanes and chloropropanes was investigated. It was found that these materials were dechlorinated enzymatically by an enzyme system located in hepatic microsomes. This system requires NADPH and oxygen, and is inducible by phenobarbital and benzpyrene, but not by methylcholanthrene. The pH optimum of this system was found to be 8.2. Evidence is presented that a factor is present in the 105,000 g supernatant which is necessary for optimum activity. This supernatant factor is not inducible. The dechlorination varied depending on the extent of chlorination of the ethane or propane.
Analysis with rat liver microsomes showed that the enzyme responsible for the dechlorination of 1,2-dichloropropane needs O2 and NADPH. Phenobarbital and benzpyrene can induce this enzyme but not methylcholanthrene.
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