Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: publication
- Adequacy of study:
- key study
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Early (pre-guideline) study. Methods and results briefly reported. Generally acceptable for assessment.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VI.
- Author:
- Smyth, HF, Carpenter, CP, Weil, CS, Pozzani, UC and|Streigel, JA
- Year:
- 1 962
- Bibliographic source:
- Ind Hyg J, March-April 1962, 95 - 107.
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII.
- Author:
- Smyth, HF, Carpenter, CP, Weil, CS, Pozzani, UC, Streigel,|JA and Nycum, JS
- Year:
- 1 969
- Bibliographic source:
- Am Ind Hyg Assoc J, Sept-Oct 1969, 470 - 476.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- None specified
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- - Name of test material (as cited in study report): 1,2-Dichloropropane.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carforth-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- The acute oral toxicity of PDC was determined in groups of non-fasted Carworth-Wistar rats (males and females, 4-5 wk old, non-fasted).
- Doses:
- PDC was administered undiluted, and doses were arranged in a logarithmic series and differed by a factor of two.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Animals were observed for 14 d post-treatment, and the LD50 calculated using the methods of Thompson (Bacteriol. Rev. (1947) 11, 115) and Weil (Biometrics (1952) 8, 249). The result is presented as the mean and SD.
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 200 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
Acute oral LD50 = 1.9 ± 0.2 ml/kg (mean and SD)
This is equivalent to 2200 ± 230 mg/kg bw, based on a density of
1.155 g/ml [Source: MacKay et al (1993) Illustrated Handbook
of Physical-Chemical Properties and Environmental Fate for
Organic Chemicals, Vol III, p479]
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study, PDC is of relatively low inherent toxicity and not classified according to EU criteria.
- Executive summary:
The acute oral toxicity of PDC was determined in groups of non-fasted Carworth-Wistar rats (males and females, 4-5 wk old, non-fasted). PDC was administered undiluted, and doses were arranged in a logarithmic series and differed by a factor of two. Animals were observed for 14 d post-treatment, and the LD50 calculated using the methods of Thompson (Bacteriol. Rev. (1947) 11, 115) and Weil (Biometrics (1952) 8, 249). The result is presented as the mean and SD.
Acute oral LD50 = 1.9 +/- 0.2 ml/kg (mean and SD).
This is equivalent to 2200 mg/kg bw, based on a density of1.155 g/ml [Source: MacKay et al (1993) Illustrated Hand book of Physical Chemical Properties and Environmental Fate for Organic Chemicals, Vol III, p479].
Based on the results of the study, PDC is of relatively low inherent toxicity and not classified according to EU criteria.
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