Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- other: review
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from handbook or collection of data.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Monograph for 1,2-dichloropropane.
- Author:
- IARC
- Year:
- 1 999
- Bibliographic source:
- Monographs on the Evaluation of Carcinogenic Risks to Humans; Volume 71: Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide (part three), IARC, Lyon, pp 1393 - 1400. IARC Monographs Supplement 7
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- Test substance: 1,2-Dichloropropane
Constituent 1
Method
- Target gene:
- no data
- Test concentrations with justification for top dose:
- no data
- Vehicle / solvent:
- no data
- Details on test system and experimental conditions:
- Type: Ames test
- Evaluation criteria:
- no data
- Statistics:
- no data
Results and discussion
- Additional information on results:
- No data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- 1,2 Dichloropropane was mutagenic to Salmonella typhimurium but not to Streptomyces coelicolor.
- Executive summary:
1,2 Dichloropropane was mutagenic to Salmonella typhimurium but not to Streptomyces coelicolor. It induced mutations weakly but not chromosomal effects in Aspergillus nidulans. It did not induce sex-linked recessive lethal mutations in Drosophila melanogaster.
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