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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
other: review
Adequacy of study:
key study
Study period:
1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Monograph for 1,2-dichloropropane.
Author:
IARC
Year:
1999
Bibliographic source:
Monographs on the Evaluation of Carcinogenic Risks to Humans; Volume 71: Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide (part three), IARC, Lyon, pp 1393 - 1400. IARC Monographs Supplement 7

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: 1,2-Dichloropropane

Method

Target gene:
no data
Test concentrations with justification for top dose:
no data
Vehicle:
no data
Details on test system and conditions:
Type: Ames test
Evaluation criteria:
no data
Statistics:
no data

Results and discussion

Additional information on results:
No data

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
1,2 Dichloropropane was mutagenic to Salmonella typhimurium but not to Streptomyces coelicolor.
Executive summary:

1,2 Dichloropropane was mutagenic to Salmonella typhimurium but not to Streptomyces coelicolor. It induced mutations weakly but not chromosomal effects in Aspergillus nidulans. It did not induce sex-linked recessive lethal mutations in Drosophila melanogaster.