1,2-dichloropropane

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

other: case report

Adequacy of study:

supporting study

Study period:

1988

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Short case report, limited reporting of methods and results. Includes an approximate dose and some available toxicological data.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference 1

Reference Type:

publication

Title:

1,2-Dichloropropane-induced Liver Toxicity: Clinical Data and Preliminary Studies in rats

Author:

Di Nucci, A. et al.

Year:

1988

Bibliographic source:

Arch. Toxicol. Suppl. 12, 370 - 374

Reference 2

Reference Type:

publication

Title:

No information

Author:

Meyer, J.G., Bellwinkel, S.

Year:

1986

Bibliographic source:

Kurzlehrbuch fuer Aerzte, Medizinstudenten und MTL, 3. Aufl., 57, 58, 63, 64, 121, 248, 249, 276

Materials and methods

Type of study / information:

Type of experience: Human

Endpoint addressed:

not applicable

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

not applicable

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,2-dichloropropane

EC Number:

201-152-2

EC Name:

1,2-dichloropropane

Cas Number:

78-87-5

Molecular formula:

C3H6Cl2

IUPAC Name:

1,2-dichloropropane

Details on test material:

as described by IUCLID 1.1-1.4

Method

Ethical approval:

not applicable

Details on study design:

not applicable

Exposure assessment:

estimated

Details on exposure:

An unconscious 71-year-old man was taken to the hospital approximately 1 hour after attempting suicide by ingesting approximately 180 ml of a cleaning agent (labelled as 90 % 1,2-dichloropropane and 10 % 1,1,1-trichloroethane.

Results and discussion

Results:

He died after 48 hours never regaining consciousness. Upon arrival his liver and renal functions as well as coagulation were normal but 8 hours later, severe liver dysfunctions appeared. These dysfunctions were detected by a strong increase of transaminase activity in serum. After 48 hours aspartate aminotransferase activity was 5,912 U/l (upper normal value 19U/l), the alanine aminotransferase was 30,128 U/l (normal value 5-23 U/l) and prothrombin activity was lower than 10%. Further, the following were measured: a bilirubin content of 2.3 mg/100 ml (normal value < 1mg/100ml), a creatinine content of 2.8mg/100ml (normal value 0.7-1.1 mg/100 ml), an increased activity of cholinesterase up to 2100 U/l, a fibrinogen content of 96 mg/100 ml (normal value 150-450 mg/100 ml) and 14000 blood platelets/ul. During the hospital stay, the patient was diagnosed with severe liver and renal dysfunction, abnormal coagulation (coagulopathy), metabolic acidosis, myocardial insufficiency and shock.

Estimated dose (180mL of 90% PDC) is 3400 mg/kg/day for a 60kg 71-year old.

Any other information on results incl. tables

none

Applicant's summary and conclusion

Conclusions:

An unconscious 71-year-old man was taken to the hospital approximately 1 hour after attempting suicide by ingesting approximately 180 ml of a cleaning agent (labelled as 90 % 1,2-dichloropropane and 10 % 1,1,1-trichloroethane). He died after 48 hours never regaining consciousness. Upon arrival his liver and renal functions as well as coagulation were normal but 8 hours later, severe liver dysfunctions appeared. These dysfunctions were detected by a strong increase of transaminase activity in serum. After 48 hours aspartate aminotransferase activity was 5,912 U/l (upper normal value 19U/l), the alanine aminotransferase was 30,128 U/l (normal value 5-23 U/l) and prothrombin activity was lower than 10%. Further, the following were measured: a bilirubin content of 2.3 mg/100 ml (normal value < 1mg/100ml), a creatinine content of 2.8mg/100ml (normal value 0.7-1.1 mg/100 ml), an increased activity of cholinesterase up to 2100 U/l, a fibrinogen content of 96 mg/100 ml (normal value 150-450 mg/100 ml) and 14000 blood platelets/ul. During the hospital stay, the patient was diagnosed with severe liver and renal dysfunction, abnormal coagulation (coagulopathy), metabolic acidosis, myocardial insufficiency and shock.

Estimated dose (180mL of 90% PDC) is 3400 mg/kg/day for a 60kg 71-year old

Executive summary:

An unconscious 71-year-old man was taken to the hospital approximately 1 hour after attempting suicide by ingesting approximately 180 ml of a cleaning agent (labelled as 90 % 1,2-dichloropropane and 10 % 1,1,1-trichloroethane). He died after 48 hours never regaining consciousness. Upon arrival his liver and renal functions as well as coagulation were normal but 8 hours later, severe liver dysfunctions appeared. These dysfunctions were detected by a strong increase of transaminase activity in serum. After 48 hours aspartate aminotransferase activity was 5,912 U/l (upper normal value 19U/l), the alanine aminotransferase was 30,128 U/l (normal value 5-23 U/l) and prothrombin activity was lower than 10%. Further, the following were measured: a bilirubin content of 2.3 mg/100 ml (normal value < 1mg/100ml), a creatinine content of 2.8mg/100ml (normal value 0.7-1.1 mg/100 ml), an increased activity of cholinesterase up to 2100 U/l, a fibrinogen content of 96 mg/100 ml (normal value 150-450 mg/100 ml) and 14000 blood platelets/ul. During the hospital stay, the patient was diagnosed with severe liver and renal dysfunction, abnormal coagulation (coagulopathy), metabolic acidosis, myocardial insufficiency and shock.

Estimated dose (180mL of 90% PDC) is 3400 mg/kg/day for a 60kg 71-year old