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EC number: 201-152-2 | CAS number: 78-87-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
1,2-Dichloropropane was not degraded in the Zahn-Wellens Test for inherent biodegradability (OECD 302B). No degradation was also observed in the Modified MITI Test (OECD 301C).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The results of biodegradation screening tests are variable. 1,2 -Dichloropropane was not degraded in the Zahn-Wellens Test for inherent biodegradability (OECD 302B). No degradation was also observed in the Modified MITI Test (OECD 301C). However, based on the supporting studies, 1,2 -dichloropropane is susceptible to biodegradation under aerobic conditions when incubated with adapted bacterial cultures, particularly those containing microbial oxygenase enzymes with broad substrate specificity. For example, 1,2 -dichloropropane was degraded by a strain of Pseudomonas sp. strain DCA1, which is capable of utilizing 1,2 -dichloroethane as a sole carbon and energy source. The compound was also degraded by nitrifying bacteria, apparently by the ammonia monooxygenase. Results of a study conducted using the Bunch and Chambers static-culture flask screening procedure showed 1,2 -dichloropropane was biodegraded by adapted microorganisms from municipal sewage. However, the findings were excluded because of concerns about potential losses of the test material due to volatilization.
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