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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-12-10 to 2008-12-11
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
EC-No. 440/2008
Deviations:
no
Principles of method if other than guideline:
NA
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
20 °C
pH:
6
Details on results:
NA

no remarks

Conclusions:
A log Pow of 0.127 was measured. This value lies outside the range of the recommended reference items. The log Pow of the test item Sodium cyanate is stated as < 0.3.
Executive summary:

A log POW  of 0.127 was measured (HPLC-Method). This value lies outside the range of the recommended reference items. Therefore, the log POW of the test item Sodium cyanate is stated as < 0.3.

Description of key information

No study is available for potassium cyanate. Read across from sodium cyanate was performed instead. In aqueous solution cyanate salts dissociate very quickly to cyanate ion and the respective alkali metal ion. It is not expected that Na+ or K+ contribute to the partition coefficient.
A log Pow  of 0.127 was measured (HPLC-Method). This value lies outside the range of the recommended reference items. Therefore, the log Pow of the test item sodium cyanate is stated as < 0.3.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.3
at the temperature of:
20 °C

Additional information

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