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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Pharmacology of cyanate. I. general Effects on experimental animals
Author:
Cerami, A.; Allen, T.A..; Graziano, J.H. deFuria, F.G.; Manning, J.M.; Gillette, P.N.
Year:
1973
Bibliographic source:
J. Pharmacol. Exp. Ther. 185: 653-666, 1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Groups of B6/D2 F1 mice were given intraperitoneally increasing doses of the test item.
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium cyanate
EC Number:
209-676-3
EC Name:
Potassium cyanate
Cas Number:
590-28-3
Molecular formula:
KOCN
IUPAC Name:
potassium cyanate
Details on test material:
not indicated.

Test animals

Species:
mouse
Strain:
other: B6/D2 F1
Sex:
not specified
Details on test animals or test system and environmental conditions:
Weight: 20 g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
not indicated.
Doses:
The mice were injected i.p. with increasing amounts of potassium cyanate.
No. of animals per sex per dose:
not indicated.
Control animals:
not specified
Details on study design:
not indicated.
Statistics:
not indicated.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
320 mg/kg bw
Based on:
test mat.
Mortality:
not indicated.
Clinical signs:
not indicated.
Body weight:
not indicated.
Gross pathology:
not indicated.
Other findings:
not indicated.

Any other information on results incl. tables

After the administration of a lethal dose, the mice appeared sedated, but then suddenly developed seizures which could be triggered by noise. Some animals recovered from several of these seizures, but eventually succumbed. The deaths after a lethal dose occurred within 15 minutes to one hour after the injection; mice that survived an LD50 dose recovered from the sedation and did not appear permanently affected.

Applicant's summary and conclusion

Conclusions:
The LD50 value was determined to be 320 mg/kg bw in mice after i.p. administration.
Executive summary:

In an acute toxicity study (i.p. administration), groups of B6/D2 F1 mice were given increasing doses of potassium cyanate.

After the administration of a lethal dose, the mice appeared sedated, but then suddenly developed seizures which could be triggered by noise. Some animals recovered from several of these seizures, but eventually succumbed. The deaths after a lethal dose occurred within 15 minutes to one hour after the injection; mice that survived an LD50 dose recovered from the sedation and did not appear permanently affected. The LD50 value was determined to be 320 mg/kg bw after i.p. administration.