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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1984-08-18 to 1984-10-02
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Version / remarks:
1984
Deviations:
no
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium cyanate
EC Number:
209-676-3
EC Name:
Potassium cyanate
Cas Number:
590-28-3
Molecular formula:
KOCN
IUPAC Name:
potassium cyanate
Details on test material:
Potassium cyanate 98 = minimum 98 % Potassium cyanate, up to 2 % Potassium carbonate

Test animals

Species:
rabbit
Strain:
other: White Russian
Details on test animals or test system and environmental conditions:
- Source: Asta-Werke, Bielefeld, Germany
- Age at study initiation: 4 - 5 months
- Weight at study initiation: 2.0 - 2.35 kg
- Housing: individually
- Diet: standardized feed (ssniff)
- Water: ad libitum
- Acclimation period: 1 day

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1
- Humidity (%): 50 - 60
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
yes, concurrent no treatment
Amount / concentration applied:
TEST MATERIAL
- Amount applied:0.5 g of test item was moistened with 0.2 mL water.
Duration of treatment / exposure:
The exposure period was 4 hours.
Observation period:
The observation period was 1, 24, 48 and 72 hours after removing of the bandage.
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: 6.25 cm^2
- Type of wrap: The gauze patch was hold in contact with the skin by means of an occlusive dressing (Acrylastic)

OBSERVATION TIME POINTS
- 1, 24, 48 and 72 hours after exposure

SCORING SYSTEM:
- Method of calculation: Draize scheme

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 1/24/48/72 h
Score:
0
Irritant / corrosive response data:
none
Other effects:
- Other adverse systemic effects: none

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Potassium cyanate is considered to be not irritating to rabbit's skin.
Executive summary:

The skin irritation/corrosion potential of the test item was investigated in primary dermal irritation study accordding to OECD Guideline 404 (1984). Three females of 4-5 month old White Russian rabbits were dermally exposed to 0.5 g (moistened with 0.2 mL water) of potassium cyanate for 4 hours to the animals back. Skin reactions were recorded after 24, 48 and 72 hours after exposure and evaluated according to the method of Draize. The erythema and edema score was 0 for each of the three animals. Furthermore, no systemic effects were observed after dermal application of the test item. 

Thus, the test item is considered to be not irritating to rabbit’s skin. 

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