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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental tests performed using standard test guidelines
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0.515
Temp.:
25 °C
Remarks on result:
other: 0.515 ± 0.023

 Test substance      K  Log k  Log Pow by Calibration Graph  Mean of Log Pow ± S.D.

Rt1

0.796

 

-0.153

 -0.815

 0.531

 0.515 ± 0.023

 Rt2

 0.800

 -0.149

 -0.827

 0.498

 
Conclusions:
The partition coefficient(n-octanol/water) of test substance was determined as per the HPLC method (OECD Guideline117). The Log Pow value was determined to be 0.515 ± 0.023 at 25°C.
Executive summary:

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared. The reference substances were Butanone, Acetophenone, 4-Methoxyphenol, Phenol, Benzophenone, 4-Acetylpyridine, Toluene, Ethylbenzene, Biphenyl, Naphthalene, Allyl phenyl ether, Benzene, n-Butylbenzene, having Pow value ranging from 0.3 to 4.6 The Log Pow value was determined to be 0.515 ± 0.023 at 25°C.

Description of key information

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared. The reference substances were Butanone, Acetophenone, 4-Methoxyphenol, Phenol, Benzophenone, 4-Acetylpyridine, Toluene, Ethylbenzene, Biphenyl, Naphthalene, Allyl phenyl ether, Benzene, n-Butylbenzene, having Pow value ranging from 0.3 to 4.6 The Log Pow value was determined to be 0.515 ± 0.023 at 25°C

indicating that the chemical is hydrophillic.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.515
at the temperature of:
25 °C

Additional information

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared. The reference substances were Butanone, Acetophenone, 4-Methoxyphenol, Phenol, Benzophenone, 4-Acetylpyridine, Toluene, Ethylbenzene, Biphenyl, Naphthalene, Allyl phenyl ether, Benzene, n-Butylbenzene, having Pow value ranging from 0.3 to 4.6 The Log Pow value was determined to be 0.515 ± 0.023 at 25°C

indicating that the chemical is hydrophillic.