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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Justification for type of information:
Experimental tests performed using standard test guidelines
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The test was conducted to determine the solubility range for which 0.1 gm of substance was dissolved in different solvents like acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF).
GLP compliance:
no
Key result
Medium:
methanol
Solubility:
> 200 - < 1 000 mg/L
Temp.:
26.7 °C
Key result
Medium:
ethanol
Solubility:
> 200 - < 1 000 mg/L
Temp.:
26.7 °C
Key result
Medium:
dimethylformamide
Solubility:
> 100 - < 200 mg/L
Temp.:
26.7 °C
Key result
Medium:
acetone
Solubility:
< 1 mg/L
Temp.:
26.7 °C
Key result
Medium:
acetonitrile
Solubility:
< 1 mg/L
Temp.:
26.7 °C
Key result
Medium:
toluene
Solubility:
< 1 mg/L
Temp.:
26.7 °C
Test substance stable:
yes
Details on results:
The solubility of sulisobenzone in acetone, acetonitrile and toluene was found to be lesser than 1mg/l, whereas the solubility value in methanol and ethanol was found to be in the range of 200 – 1000mg/l and DMF was found to be in the range of 100-200mg/l, respectively at 26.7 °C.

The solubility of sulisobenzone in acetone, acetonitrile and toluene was found to be lesser than 1mg/l, whereas the solubility value in methanol and ethanol was found to be in the range of 200 – 1000mg/l and DMF was found to be in the range of 100-200mg/l, respectively at 26.7 °C.

Conclusions:
The solubility of test chemical in acetone, acetonitrile and toluene was determined to be lesser than 1mg/l, whereas the solubility value in methanol and ethanol was determined to be in the range of 200 – 1000mg/l and DMF was determined to be in the range of 100-200mg/l, respectively at 26.7 °C.
Executive summary:

The solubility of test chemical in acetone, acetonitrile and toluene was determined to be lesser than 1mg/l, whereas the solubility value in methanol and ethanol was determined to be in the range of 200 – 1000mg/l and DMF was determined to be in the range of 100-200mg/l, respectively at 26.7 °C.

Description of key information

The solubility of test chemical in acetone, acetonitrile and toluene was determined to be lesser than 1mg/l, whereas the solubility value in methanol and ethanol was determined to be in the range of 200 – 1000mg/l and DMF was determined to be in the range of 100-200mg/l, respectively at 26.7 °C.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
200 mg/L

Additional information

The solubility of test chemical in acetone, acetonitrile and toluene was determined to be lesser than 1mg/l, whereas the solubility value in methanol and ethanol was determined to be in the range of 200 – 1000mg/l and DMF was determined to be in the range of 100-200mg/l, respectively at 26.7 °C.