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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal
Justification for type of information:
Data is from peer reviewed journal
Qualifier:
according to
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Principles of method if other than guideline:
21 d reproduction study performed according to OECD guideline 211.
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
21 d
Nominal and measured concentrations:
five concentrations ranging between 0.128–5 mg/L
Details on test conditions:
Renewal of medium took place every 48 h, and the offsprings produced by each parent animal were counted daily.
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.128 - 5 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
reproduction
Details on results:
No adverse effects on either the number or sex of offsprings,or body size were observed after exposure to five concentrations of the test substance (0.128–5 mg/L).
Conclusions:
Long term toxicity (21 d) value of test material to Daphnia magna resulted in a no observed effect concentration ( NOEC) ranging between 0.128–5 mg/L.
Executive summary:

21 d reproduction study performed according to OECD guideline 211. Renewal of medium took place every 48 h, and the offsprings produced by each parent animal were counted daily. The exposure concentration was in the range of a tenth of the acute toxicity value. No adverse effects on either the number or sex of offsprings, or body size were observed after exposure to five concentrations each .Long term toxicity (21 d) value of sulisobenzone (benzophenone-4) to Daphnia magna resulted in a no observed effect concentration ( NOEC) ranging between 0.128–5 mg/L. Based on the above effect concentration it is considered to be non - hazardous to aquatic environment and can not be classified as per CLP criteria .

Description of key information

Long term toxicity to aquatic invertebrate:

21 d reproduction study performed according to OECD guideline 211. Renewal of medium took place every 48 h, and the offsprings produced by each parent animal were counted daily. The exposure concentration was in the range of a tenth of the acute toxicity value. No adverse effects on either the number or sex of offsprings, or body size were observed after exposure to five concentrations each .Long term toxicity (21 d) value of sulisobenzone (benzophenone-4) to Daphnia magna resulted in a no observed effect concentration ( NOEC) ranging between 0.128–5 mg/L. Based on the above effect concentration it is considered to be non - hazardous to aquatic environment and can not be classified as per CLP criteria .

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
5 mg/L

Additional information

Long term toxicity to aquatic invertebrate:

21 d reproduction study performed according to OECD guideline 211. Renewal of medium took place every 48 h, and the offsprings produced by each parent animal were counted daily. The exposure concentration was in the range of a tenth of the acute toxicity value. No adverse effects on either the number or sex of offsprings, or body size were observed after exposure to five concentrations each .Long term toxicity (21 d) value of sulisobenzone (benzophenone-4) to Daphnia magna resulted in a no observed effect concentration ( NOEC) ranging between 0.128–5 mg/L. Based on the above effect concentration it is considered to be non - hazardous to aquatic environment and can not be classified as per CLP criteria .