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EC number: 225-642-0
CAS number: 4985-85-7
INDIVIDUAL CAGE-SIDE OBSERVATIONS
Day of occurence
Active and healthy
0(1-4.5 hrs), 8-14
Erythema at dose site
Desquamation at dose site
0(1-4.5 hrs), 4-14
0(1-4.5 hrs), 7-14
Small areas of eschar at dose site
Areas of dark discoloration at dose site
Eschar at dose site
0(1-4.5 hrs), 14
0 (1-4.5 hrs), 14
0(1-4.5 hrs), 12-14
Areas of dark disco1oration at dose site
Active and healthy
An acute dermal toxicity test was conducted with rats to determine the
potential for N-(3-Aminopropyl)diethanolamine
Two thousand milligrams of the test substance per kilogram of body
weight was applied to the skin of ten healthy rats for 24 hours. The
animals were observed for mortality, signs of gross toxicity, and
behavioral changes at least once daily lor 14 days. Body weights were
recorded prior to application and again on Days 7 and 14 (termination).
Necropsies were performed on all animals at terminal sacrifice. All
animals survived exposure to the test substance during the study. Dermal
irritation was noted at the dose site of all animals between Days 1 and
14. Although two females lost weight through Day 7, all animals gained
body weight over the 14-day observation period. No gross abnormalities
were noted for any of the animals when necropsied at the conclusion of
the 14-day observation period.
Under the conditions of this study, the single dose acute dermal LD0 of
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