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EC number: 225-642-0
CAS number: 4985-85-7
The study was performed to assess the acute oral toxicity of
N-(3-Aminopropyl)diethanolamine in the Sprague-Dawley CD strain rat. The
method followed that in the OECD Guidelines for Testing of Chemicals No.
401 "Acute Oral Toxicity" (adopted 24 February 1987), Method 81 of
Commission Directive 92/69/EEC (which constitutes Annex V of Council
Directive 67/548/EEC) and the US Environmental Protection Agency (EPA)
Health Effects Test Guidelines OPPTS 870:1100, 1998.
Following a range-finding study, a group of ten fasted animals (five
males and five females) was given a single oral dose of undiluted test
material at a dose level of 2268 mg/kg bodyweight (equivalent to 2000 mg
active ingredient/kg bodyweight).
The animals were observed for fourteen days after the day of dosing and
were then killed and subjected to gross pathological examination.
There were no deaths. No signs of systemic toxicity were noted during
All animals showed an expected gain in bodyweight during the study.
No abnormalities were noted at necropsy.
The acute oral LD0 of the test material in the Sprague-Dawley CD strain
rat was found to be greater than 2000 mg active ingredient/kg bodyweight.
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