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EC number: 700-597-4
CAS number: 1215841-86-3
irritation/corrosion test of trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide
Examination of the treated eye
C O R N E A
I R I S
C O N J U N C T I V A E
A n i m a l n o. : 1 / 2 / 3
right eye: 100 mg test item
purpose of this study was to obtain information on the influence of trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide
on rabbit eyes (irritation/corrosion test),
according to OECD guideline 405, EC method B.5. and OCSPP
Under the present test conditions a single administration of the
test item per animal into the conjunctival sac of the right eye of three
rabbits caused following effect:
Conjunctival redness (grade 1) was observed in all animals
only 1 hour after instillation.The effect was reversible within 24 hours.
The corneae and irises were not affected by
instillation of the test item. There were no systemic intolerance
reactions.Therefore, according to the EC Regulatiom 1272/2008 and
subsequent regulations on classification, labelling and packaging of
substances and mixtures, trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide
is non-irritating to eyes, hence, no labelling is required.
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