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EC number: 700-597-4
CAS number: 1215841-86-3
The substance trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide was examined regarding skin irritation properties and eye irritation properties in rabbits. Under the conditions of the studies the substance showed no skin irritation and no relevant eye irritation in rabbits.
Studies in animals:
was examined for acute dermal irritation/corrosion properties in rabbits
(patch test),according to OECD Guideline 404. Under the present test
conditions, none of the three male rabbits exposed for 4 hours to 500 mg
(semi-occlusive conditions) showed any skin reaction. There were no
systemic intolerance reactions.
The influence of the substance
on rabbit eyes (irritation/corrosion test) was examined according to
OECD guideline 405.
Under the present test conditions a single administration of the
test item per animal into the conjunctival sac of the right eye of three
rabbits caused following effect:
Conjunctival redness(grade 1) was observed in all animals
only 1 hour after instillation. The effect was reversible within 24
The corneae and irises were not affected by
instillation of the test item. There were no systemic intolerance
reactions.Therefore, according to the EC Regulatiom 1272/2008 and
subsequent regulations on classification, labelling and packaging of
substances and mixtures,
is non-irritating to eyes.
According to the criteria of EC Directive 67/548/EEC and EC
Regulation 1272/2008 and subsequent regulations on classification,
labelling and packaging of substances and mixtures and based on the
results of the studies
is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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