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EC number: 700-597-4
CAS number: 1215841-86-3
no further remarks
The aim of the present experiment was to obtain information on the
acute toxicity and LC50, following a single 4-hour inhalation exposure
in an acute inhalation study in rats.
3 male and 3 female rats were exposed to trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide
at a concentration of 5.07±0.01 mg test substance/L air for 4 hours by
inhalation using a dynamic nose-only exposure chamber. The aerosol was
generated with the aid of a dry, rotating brush dust generator. In the
inhalation chamber, close to the animals' noses, the generated aerosol
particulates had a mass median aerodynamic diameter (MMAD) of 3.615 µm
as determined with a cascade impactor. The Geometric Standard Deviation
(GSD) of the MMAD was calculated as 2.85.
Under the present test conditions, a 4-hour inhalation LC50 of trans-N1,N1,N4,N4-Tetrakis(2-hydroxyethyl)1,4-cyclohexanedicarboxamide
revealed slight ataxia and slight dyspnoea immediately until 60 minutes
or 3 hours after end of exposure. No animal died prematurely. No
pathological findings were noted at necropsy. One of the 3 female
animals appeared to be reduced in body weight gain.
Therefore LC50 exceeding 5.07 mg/L air for both sexes combined.
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