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EC number: 701-218-5
CAS number: -
Compared to vehicle-treated animals, also none of the other parameters
measured in the substance-treated groups, i.e. weights of the draining
lymph nodes, ear weights and ear swelling, reached or exceeded the
"positive levels" defined for this assay.
weight index: 1.00 (0 %) / 0.85 (2 %) / 0.96 (10 %) / 0.93 (50 %)
ear swelling: day 1 = 17.75 (0 %) / 17.75 (2 %) / 18.25 (10 %) / 17.83
(50 %); day 4 = 18.00 (0 %) / 18.00 (2 %) / 18.42 (10 %) / 18.25 (50 %); Index
day 4 = 1.00 (0 %) / 1.00 (2 %) / 1.02 (10 %) / 1.01 (50 %)
ear weight: day 4 = 13.66 (0 %) / 13.43 (2 %) / 12.96 (10 %) / 13.16 (50
%); Index day 4 = 1.00 (0 %) / 0.98 (2 %) / 0.95 (10 %) / 0.96 (50 %).
The body weights of the animals were not affected by any treatment. This
study does neither point to a non-specific (irritant) nor to a specific
irnmunostimulating (sensitizing) potential of the test item.
A modified LLNA (IMDS; OECD TG 429) was performed on 6 female NMRI mice
per dose group using epicutaneously applied test substance of 0 %
(vehicle control), 2 %, 10 % and 50 %. The study does neither point to a
non-specific (irritant) nor to a specific immunostimulating
(sensitizing) potential of the test item. Therefore, the concentration
of 50 % turned out to be the NOEL for the parameters investigated
(weight and cell counts of the draining lymph nodes, ear swelling, ear
weight) with respect to skin sensitization.
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