Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
2 000 mg/kg bw

Additional information

An Acute Oral Toxicity study according to OECD 423 conducted on female rats revealed no mortalities, no clinical signs and no effects on body weight gain up to the limit dose of 2000 mg/kg bw. At necropsy no gross pathological findings were observed. The LD50 was estimated from the flow chart of the OECD TG 423, Annex 2d, to be >/= 5000 mg/kg bw.

No study on acute inhalation toxicity is available for the substance.

An Acute Dermal Toxicity study according to OECD TG 402 with a limit dose of 2000 mg/kg, applied semiocclusive on the skin of 5 male and 5 female rats for 24 hours, also revealed no mortalities, no clinical signs, no effects on body weight development and no gross pathological findings. The resulting LD50 was therefore > 2000 mg/kg bw for both sexes combined.

Justification for classification or non-classification

No classification required for acute toxicity according to Regulation (EC) No 1272/2008, Annex I.