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The following remarks on the toxicokinetics of 2-benzofuran-1,3-dione, addition product with 2-(2-hydroxyethoxy)ethanol, ethoxylated are based on physicochemical properties of the compound and on toxicological data. Experimental toxicokinetic studies were not performed.

The substance is a colourless, clear organic liquid (Currenta, 2008) with a low vapour pressure under normal ambient conditions (8.9 Pa at 20 °C, 12.8 Pa at 25 °C, Currenta, 2009; 0.00513 Pa at 20 °C, Laus GmbH, 2010). Inhalation exposure via vapour is therefore not to be expected. Absorption of the substance via skin or mucosa could not be ruled out due to water solubility (4 g/L at 20 °C, CURRENTA, 2009) and a log Pow of 1.6, however due to the high average molecular weight of the substance it is expected to be low. In fact, no indications for systemic availability could be observed after acute oral or dermal exposure to the substance as there were no toxicological effects at all reported (OECD TG 423 and 402, both Gillissen, 2009). Also no indications of systemic availability appeared in a developmental toxicity study (OECD TG 414, Langewische, 2010) as no adverse effects were observed for the dams and for the offspring. Hints for systemic availability were seen in an oral repeated dose toxicity study where only for male rats of the high dose group (1000 mg/kg bw) slight effects on livers were observed (OECD TG 407, Potthoff, 2010).

There are no indications for irritating properties of the substance (OECD TG 404 and 405, both Gmelin, 2009) which might influence skin or mucosa barrier function and thus systemic availability.

Deducing from the repeated dose toxicity study where no other substance-related effects except liver findings were reported and from the above specified log Pow, no potential for accumulation is to be expected for the substance.

Based on the results of the genotoxicity tests in vivo and in vitro (OECD TG 471, Herbold, 2009; OECD TG 476, Entian, 2009; OECD TG 473, Nern, 2009) it could be concluded that DNA-reactive metabolites most probably will not be generated in mammalian organisms due to hepatic biotransformation.