Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: -
CAS number: -
The following remarks on the toxicokinetics of 2-benzofuran-1,3-dione,
addition product with 2-(2-hydroxyethoxy)ethanol, ethoxylated are based
on physicochemical properties of the compound and on toxicological data.
Experimental toxicokinetic studies were not performed.
The substance is a colourless, clear organic liquid (Currenta, 2008)
with a low vapour pressure under normal ambient conditions (8.9 Pa at 20
°C, 12.8 Pa at 25 °C, Currenta, 2009; 0.00513 Pa at 20 °C, Laus GmbH,
2010). Inhalation exposure via vapour is therefore not to be expected.
Absorption of the substance via skin or mucosa could not be ruled out
due to water solubility (4 g/L at 20 °C, CURRENTA, 2009) and a log Pow
of 1.6, however due to the high average molecular weight of the
substance it is expected to be low. In fact, no indications for systemic
availability could be observed after acute oral or dermal exposure to
the substance as there were no toxicological effects at all reported
(OECD TG 423 and 402, both Gillissen, 2009). Also no indications of
systemic availability appeared in a developmental toxicity study (OECD
TG 414, Langewische, 2010) as no adverse effects were observed for the
dams and for the offspring. Hints for systemic availability were seen in
an oral repeated dose toxicity study where only for male rats of the
high dose group (1000 mg/kg bw) slight effects on livers were observed
(OECD TG 407, Potthoff, 2010).
There are no indications for irritating
properties of the substance (OECD TG 404 and 405, both Gmelin, 2009)
which might influence skin or mucosa barrier function and thus systemic
Deducing from the repeated dose toxicity
study where no other substance-related effects except liver findings
were reported and from the above specified log Pow, no potential for
accumulation is to be expected for the substance.
Based on the results of the genotoxicity
tests in vivo and in vitro (OECD TG 471, Herbold, 2009; OECD TG 476,
Entian, 2009; OECD TG 473, Nern, 2009) it could be concluded that
DNA-reactive metabolites most probably will not be generated in
mammalian organisms due to hepatic biotransformation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again