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EC number: 252-552-9
CAS number: 35415-27-1
Recovery of radioactivity was 94.1% of the administered dose.
In this study absorption, metabolism and excretion of [Hexyl-2 -14C]
tri-(2 -ethylhexyl)trimellitate (TOTM, 97.1% purity) were investigated.
To this end, 100 mg TOTM/ kg bodyweight were administered via gavage to
each of four fasted male Sprague-Dawley rats. Animals were placed in
separate metabolism cages and faeces, urine and expired air were
collected at 4, 8, 12, 24, 36, 48, 72, 96, 120 and 144 hours post
dosing. At the end of the study animals were killed, various tissues
were removed and radioactivity was analysed. The overall recovery of
radioactivity was 94.1%.
75% of the administered dose were excreted via the faeces. In urine and
expired air 16.3% and 1.9% of radioactivity were found, respectively.
In faeces, 86% of the radioactivity accounted for TOTM, and only 7%
di-(2-ethylhexyl)trimellitate and 1% mono-(2 -ethylhexyl)trimellitate
were indetified (remark: only one of the three possible mono-esters was
identified). In urine, metabolites identified were 2-ethylhexanol,
2-ethylhexanoic acid, 2-heptanone and mono-(2-ethylhexyl)trimellitate.
Comparison to HPLC retention times indicated that the mono-ester was the
identical isomer as found in faecal extracts. No isomers of
di-(2-ethylhexyl)trimellitate were found. Urinary elimination of
radioactivity was bi-phasic with half-lives of 3.1 and 42 hours. For
expired air, two peaks in the plot of the rate of excretion of 14CO2
were observed in the treated rats. The first occuring 2-3 hours post
dose and the second 8-12 hours post dose. At the end of the study only
<0.6% of the administered dose was remainig in the carcass. Tissues
analysed for radioactivity revealed only liver (5x) and adipose tissue
(3x) showing concnetrations of radioactivity greater than the carcass
In conclusion these results indicate that TOTM is only partially
hydrolised in the gastrointestinal tract to 2-ethylhexanol, and
respective di - and mono-esters. Only 2 -ethylhexanol and mono-ester
were absorbed. Only 2 -ethylhexanol seems to be further metabolised and
exrected in urine and to 14CO2 in expiration air. As
mono-(2ethylhexyl)trimellitate was excreted unchanged no metabolism was
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