Trinonyl benzene-1,2,4-tricarboxylate

Long-term toxicity to aquatic invertebrates

Description of key information

No chronic toxicity data on aquatic invertebrates for the submission substance is available. However adequate and reliable data for structural analogues is available (i.e. C8TM and C8C10TM, for read-across justification please see read-across report in section 13). The derived 21d-NOEC (Daphnia magna, reproduction) = 4.4 mg/L (corrected for the molecular weight of the target substance).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

4.4 mg/L

Additional information

No chronic aquatic toxicity data for the submission substance is available. However adequate and reliable data for structural analogues (i.e. C8TM and C8C10TM, for read-across justification please see read-across report in section 13) are reported below.

In a reliable long-term toxicity study on daphnids (according to OECD 211 and in compliance with GLP, MoE Japan, 2001, RL1), significant effects on lethality of parent daphnids and reproduction were observed during 21 days of exposure (analogue substance: trioctyl benzene-1,2,4-tricarboxylate, trioctyl ester, C8TM, CAS no. 89-04-3) only at concentrations well above the water solubility limit. All tested concentrations lay above the water solubility of the test substance (solubilizer was used). No significant adverse effects were observed in concentrations up to 4.04 mg/L (corresponding to 4.4 mg/L of the target substance), and in the limit test of the supporting study at 4.5 mg/L (OECD 211, GLP, Huels AG, 1997, RL2; analogue substance: 1,2,4-benzenetricarboxylic acid, mixed decyl and octyl triesters, C8C10TM, CAS no. 90218-76-1; corresponding to 4.2 -4.9 mg/L of the target substance). In conclusion, no long-term toxicity to daphnia is expected below the water solubility of the analogue and submission substance.