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EC number: 252-552-9
CAS number: 35415-27-1
Key values for acute aquatic toxicity
Aquatic plants: 72h-EC50 (green algae, growth rate) > 54 mg/L
Invertebrates: 48h-EC50 (Daphnia magna, immobility) > 108 mg/L
Fish: 96h-LC50 (Oryzias latipes, mortality) > 108 mg/L
In conclusion, no acute aquatic toxicity is expected for the submission
substance below its water solubility limit.
Key values for chronic aquatic toxicity
Aquatic plants: 72h-NOECr (green algae, growth rate) = 27 mg/L
Invertebrates: 21d-NOEC (Daphnia magna, reproduction) = 4.4 mg/L
In conclusion, no long-term aquatic toxicity is expected below the water
solubility of the submission substance.
Key values for toxicity to microorganisms
Microorganisms: 4.75h-EC10 (Pseudomonas putida, respiration) > 915 -
1060 mg a.i./L
In conclusion, no toxicity to microorganisms is expected below the water
solubility of the submission substance.
No aquatic toxicity data for the submission substance is available.
However adequate and reliable data for structural anologues (i.e. C8TM
and C8C10TM, for read-across justification please see read-across report
in section 13) are reported below.
Acute aquatic toxicity
Reliable key acute toxicity studies for aquatic plants, invertebrates
and fish are available (OECD guideline sudies: MoE Japan, 2001, RL1,
analogue substance: trioctyl benzene-1,2,4-tricarboxylate, trioctyl
ester, C8TM, CAS no. 89-04-3). In addition, two supporting studies are
available for daphnia (Huels AG, 1994, RL2 and ICI GEL, 1990, RL4;
analogue substance: 1,2,4-benzenetricarboxylic acid, mixed decyl and
octyl triesters, C8C10TM, CAS no. 90218-76-1), and one reliable
supporting study is available for aquatic plants and fish (Huels AG,
1994, RL2). All key studies and most of the supporting studies were
performed in compliance with GLP. Solubilizers were used to increase the
low water solubility of the test substances. Analytically verification
of the test concentrations was available. No acute toxicity was observed
in algae, daphnia or fish.
Chronic aquatic toxicity
With regard to the toxicity studies on aquatic plants, long-term effects
on growth rate were observed after 72 hours of exposure, but not on
yield of biomass. The tested concentrations lay above the water
solubility of the test substance, except for the lowest of measured
concentrations, 0.79 mg/L. No significant adverse effects were observed
in concentrations up to 25 mg/L (corresponding to 27 mg/L of the target
substance). Test concentrations of the supporting study lay below the
water solubility (lowest at nominal 0.24 mg/L), and no effects were
observed up to the highest test concentration of 3.5 mg/L (corresponding
to 3.3 -3.8 mg/L of the target substance). Therefore, no toxicity to
green algae is expected below the water solubility of the submission
Reliable chronic toxicity studies for aquatic invertebrates are
available (one key (MoE Japan, 2001, RL1, analogue substance: C8TM) and
one supporting study (Huels AG, 1997, RL2, analogue substance: C8C10TM),
according to OECD 211). The studies were performed in compliance with
GLP. Solubilizers were used to increase the low water solubility of the
test substances. Analytically verification of the test concentrations is
available. Significant effects on lethality of parent daphnids and
reproduction were observed during 21 days of exposure; however, all
tested concentrations lay above the water solubility of the test
substance. No significant adverse effects were observed in
concentrations up to 4.04 mg/L (corresponding to 4.4 of the target
substance), and in the limit test of the supporting study at 4.5 mg/L
(corresponding to 4.2 -4.9 mg/L of the target substance). Therefore, no
long-term toxicity to daphnia is expected below the water solubility of
the submission substance.
No long-term toxicity study on fish is available; however, no long-term
toxicity to fish is expected because neither short-term toxicity to
fish, aquatic invertebrates and plants nor long-term toxicity to aquatic
invertebrates was observed below the water solubility of the test
Toxicity to microorganisms
Microorganism toxicity was assessed in a reliable activated sludge
respiration inhibition study (Huels Method, Huels AG, 1994, RL2,
analogue substance: C8C10TM) and in compliance with GLP. No effect on
respiration (biochemical oxygen demand) was observed during 4.75 hours
of exposure to three concentrations up to 980 mg a.i./L test substance
(nominal 1000 mg/L, use of solubilizer; corresponding to 915 -1060 and
933 -1083 mg/L of the target substance). No analytical verification of
the test concentrations was performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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