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EC number: 923-725-2
CAS number: -
In a sub-acute gavage study in male and female Wistar rats oral application of up to 1000 mg/kg bw/day (related to dry mass) for 14 days did not result in clinical signs, effects on body weight or food consumption, in relevant macroscopical changes at necropsy or effects on organ weights.In a sub-chronic gavage study according to OECD Guideline 408 in male and female Wistar rats no effects of toxicological relevance were detected even at the high dose level of 1000 mg/kg bw/day (related to dry mass).
In a subacute 14 -Days dose range finding study with Biofert Plusz, dose
levels of 100, 300 and 1000 mg/kg bw/day (related to dry mass) were
administered once daily by gavage to Wistar rats of both sexes (n=5 per
sex per dose). Parameters investigated were clinical signs, body weights
and food consumption, organ weights and macroscopic findings. None of
these parameters was changed by the test item at any of the dose levels
Oral administration of undiluted test item via gavage to male and female
Wistar rats (n=10 per dose per sex; once weekly, 7 days per week) at
dose levels of 100, 300 and 1000 mg/kg bw/day (related to the dry mass
corresponding to 0, 356, 1068, 3559 mg/kg bw/day of the liquid test
item), for 91 days resulted in no mortality, no clinical signs (daily or
weekly), no changes to the functional observational battery, no changes
in mean daily food consumption or body weight development, no effects
upon hematology, clinical biochemistry or urinalysis parameters, no
changes in mean absolute or relative organ weights, and no
toxicologically relevant macroscopical or microscopical changes. Based
on the results of this study, the NOEL and NOAEL are > or = 1000 mg/kg
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