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EC number: 923-725-2
CAS number: -
Short-term toxicity to fish
The acute toxicity of Biofert Plusz towards Danio rerio was
investigated in a study conducted according to OECD Guideline 203 (Fish,
Acute Toxicity Test) under semi-static conditions. Fish were exposed for
96 h to mean measured Biofert Plusz concentrations ranging from 222 to
3861 mg fresh weight/L corresponding to 62.3 -1085 mg dry matter/L.
Analytical monitoring of test material concentration was performed by
HPLC and quantification of the main component (L-Threonine). The 96 h
LC50 was determined to be 738 mg dry matter/L (effective).
Long-term toxicity to fish
results are not available.
Annex IX of Regulation (EC) No 1907/2006, it is laid down that chronic
fish toxicity tests shall be proposed by the registrant if the
chemical safety assessment indicates the need to investigate further the
effects on fish. According
to Annex I of this regulation, the chemical safety assessment triggers
further action when the substance or the preparation meets the criteria
for classification as dangerous according to Directive 67/548/EEC orDirective
1999/45/EC or is assessed to be a PBT or vPvB. The
hazard assessment of Biofert Plusz reveals
neither a need to classifythe
substance as dangerous for the environment, nor is it aPBTor
nor are there any further indications that the substance may be
hazardous to aquatic organisms. According
to reliable study results, Biofert Plusz is considered to be
rapidly degraded in the environment and the bioaccumulation potential is
regarded to be insignificant. Moreover, the amino acid threonine as the
main constituent, is an essential protein constituent in living
organisms and so no metabolites are expected to occur that pose a
significant risk to living organisms. Therefore,
with respect to animal welfare, the performance of a chronic fish study
is assumed to be scientifically not justifiable.
Short-term toxicity to aquatic invertebrates
The acute toxicity of Biofert Plusz towards Daphnia magna was
investigated in a study conducted according to OECD Guideline 202
(Daphnia sp. Acute Immobilisation Test). 20 daphnids (5
daphnids/replicate) were exposed to Biofert Plusz for 48 h at nominal
concentrations ranging from 469 to 3559 mg/L corresponding 132 -1000 mg
dry matter/L to under semi-static conditions. The test material
concentration was determined by HPLC based on L-Threonine (main
component) measurements. The 48 h EC50 was determined to be 677 mg dry
matter/L (nominal). Moreover, a 48 h NOEC=444 mg dry matter/L and a
LOEC=667 mg dry matter/L were found.
Long-term toxicity to aquatic invertebrates
results are not available.
Toxicity to algae and cyanobacteria
The toxicity of Biofert Plusz towards the unicellular green alga
Desmodesmus subspicatus was investigated in a study conducted according
to OECD Guideline 201 (Alga, Growth Inhibition Test). Cultures of
Desmodesmus subspicatus were exposed to 5 Biofert Plusz concentrations
ranging from 339 to 3559 mg/L test material (nominal) corresponding to
geometric mean measured concentrations ranging from 126 to 1579 mg/L
test material. The concentration of the main component of Biofert Plusz
L-Threonine was determined by HPLC/UV. Based on geometric mean measured
concentrations the 72 h ErC50 and 72 h EyC50 were determined to be 528
and 254 mg fresh material/L, respectively, corresponding to 148 (ErC50)
and 71.4 mg dry matter/L (EyC50).
Toxicity to microorganisms
The respiration inhibition of Biofert Plusz was investigated in a study
conducted according to OECD Guideline 209. Non-adapted activated sludge
was exposed to a Biofert Plusz concentration of 3560 mg/L nominal for 3
h under static conditions. Biofert Plusz was found to be not toxic to
activated sludge at the concentration tested (3 h IC0=3560 mg/L nominal;
corresponding to 1000 mg test material dry matter/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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