Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 923-725-2
CAS number: -
In Wistar rats no maternal and developmental toxicity was detected in a gavage study according to OECD Guideline 414 even at the high dose level of 1000 mg/kg bw/day (related to dry weight) which corresponds to the limit dose recommended in the Guideline.
In a dose-range-finding study (limited validity concerning maternal and
developmental toxicity) 5 pregnant Wistar rats were gavaged with 0, 100,
300, 1000 mg/kg bw/day (related to dry mass) at day 6 -20 post coitum.
No maternal toxicity was evident (all rats with live fetuses; no
clinical signs; no effects on food consumption, mean body weight and
body weight gain, no effects on corrected body weight gain or
reproduction parameters). Necropsy at day 21 post coitum revealed no
test item-related findings. No treatment-related effects were found on
the fetal sex ratio, fetal body weights, and no abnormal findings during
external examination. Therefore, dose levels of 100, 300 and 1000 mg/kg
bw /day (related to dry mass) were considered appropriate for a main
prenatal developmental toxicity study in the rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again