Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 923-725-2 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: read-across substance - reliable published literatur study and peer reviewed book
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Exploring QSAR: Hydrophobic, Electronic, and Steric Constants
- Author:
- Hansch etal.
- Year:
- 1 995
- Bibliographic source:
- cited in Hansch etal., Exploring QSAR: Hydrophobic, Electronic, and Steric Constants, ACS Professional Reference Book, p10, 1995, USA
- Reference Type:
- publication
- Title:
- Measurement and correlation of partition coefficients of polar aminoacids
- Author:
- Yunger etal.
- Year:
- 1 981
- Bibliographic source:
- References R1207 in Hansch etal., 1995 and Sangster etal., 2006 in Mol. Pharmacol., 20(3), 602-608 (1981)
- Reference Type:
- publication
- Title:
- LOGKOW A databank of evaluated octanol-water partition coefficients (Log P)
- Author:
- Sangster etal
- Year:
- 2 006
- Bibliographic source:
- Sangster Research Laboratories P.O. Box 49562 CSP du Musée 5122 Cote des Neiges Montréal, Québec, Canada H3T 2A5
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- other: measured
Test material
- Reference substance name:
- L-threonine
- EC Number:
- 200-774-1
- EC Name:
- L-threonine
- Cas Number:
- 72-19-5
- Molecular formula:
- C4H9NO3
- IUPAC Name:
- L-threonine
- Test material form:
- not specified
- Details on test material:
- Formula: C4H9NO3
Name: L-Threonine
CAS No.: 72-19-5
SMILES: OC(C)C(N)C(=O)O
Constituent 1
Study design
- Analytical method:
- other: radiochemical method
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -2.94
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- - ion-corrected to neutral form
Applicant's summary and conclusion
- Conclusions:
- the log pow was measured at -2,94 (20 °C, pH=7.0).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
