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EC number: 246-467-6
CAS number: 24801-88-5
Analysis of variance testing indicated significant sex-related
differences in the incidence of micronuclei so data were analysed and
reported separately. No statistically significant increases in any
treatment group sampled at 30 and 72 hours. Statistically significant
increases were observed with female mice sampled at 48 hours, but
these were the result of an unusually low value in the vehicle control
group compared with historical values, and so were not considered to
be of biological significance. The positive control group produced
highly significant increases in numbers of micronuclei. The vehicle
control values were low and within an acceptable range.
1:Results of in vivo micronucleus
test with MALE Swiss-Webster mice (30 hours)
Number of cells evaluated
Sampling time (h)
Number of erythrocytes
polychromatic with micronuclei
Ratio of erythrocytes
polychromatic / normochromatic
polychromatic with micronuclei / normochromatic
2:Results of in vivo micronucleus
test with FEMALE Swiss-Webster mice (30 hours)
Number of erythro-cytes
3:Results of in vivo micronucleus
test with MALE Swiss-Webster mice (48 hours)
4:Results of in vivo micronucleus
test with FEMALE Swiss-Webster mice (48 hours)
5:Results of in vivo micronucleus
test with MALE Swiss-Webster mice (72 hours)
Results of in vivo micronucleus test with FEMALE Swiss-Webster
mice (72 hours)
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