Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-467-6
CAS number: 24801-88-5
No specific test data for skin
sensitisation are available for triethoxy(3-isocyanatopropyl)silane.
However, isocyanates are known skin sensitisers with many references in
the open literature (see for example the HSDB database). It is therefore
reasonable to conclude that triethoxy(3-isocyanatopropyl)silane could
cause skin sensitisation.
There is good evidence to indicate
that isocyanates: cause chemical bronchitis/pneumonitis; are potent
pulmonary sensitisers capable of causing “isocyanate asthma”; cause
nonspecific airways disease, including chronic bronchitis; can induce a
general asthmatic state; and can cause hypersensitivity pneumonitis.
Similar dose-response relationships are seen for both acute and chronic
effects (Musk et al., 1988).
American Journal of Industrial Medicine, Vol 13, Issue 3, pages 331-349
Isocyanates cause asthma, the symptoms of which include coughing,
shortness of breath, wheezing, and chest tightness. Symptoms can occur
soon after exposure or several hours later. Isocyanates can also cause
hypersensitivity pneumonitis, a lung disease whose symptoms include
fever, body aches, shortness of breath, and cough with phlegm or sputum.
About one out of twenty people who work with isocyanates becomes
"sensitised" to them. Being "sensitised" to isocyanates means an asthma
attack may occur at any time when expose occurs, even to extremely small
amounts. Sensitivity to isocyanates can be permanent. Also, continuing
to work with isocyanates after becoming sensitised can cause asthma
itself to become permanent, so that attacks can occur even without any
further exposure to isocyanates. Once sensitised, an individual cannot
continue to work in any job where expose to isocyanates is possible. It
is possible to become sensitised to isocyanates without ever having had
any other symptoms of overexposure. There is no evidence that people
with other allergies are more likely to become sensitised to
isocyanates. Daily exposure to levels of isocyanates too low to cause
sensitisation or cause asthma or pneumonitis may still cause a reduction
in lung capacity and function
Data for the hydrolysis product, 3-aminopropyl(triethoxy)silane (CAS
919-30-2), have been added to the dataset as supporting information for
completeness, but are not used in the assessment as the skin and
respiratory sensitisation potential of the parent substance are
determined by the isocyanate group.
Based on data for isocyanates,
triethoxy(3-isocyanatopropyl)silane requires classification for skin
sensitisation Cat 1A and respiratory sensitisation Cat 1A with hazard
statements 'H317: May cause an allergic skin reaction' and 'H334: May
cause allergy or asthma symptoms or breathing difficulties if inhaled'
according to Regulation (EC) No 1272/2008. The intermediate hydrolysis
product 3-aminopropyl(triethoxy)silane is also classified as Skin
Sensitiser Cat 1B according to Regulation (EC) No 1272/2008, as amended,
on the basis of reliable measured data (Pharmakon USA, 1997).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again