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EC number: 246-467-6
CAS number: 24801-88-5
No sediment toxicity data are
available with the registered substance.
In accordance with Column 2 of
REACH Annex IX, there is no need to further investigate the effects of
this substance in long-term sediment toxicity studies because, as
indicated in guidance R.7.8.10 (ECHA 2016), the quantitative chemical
safety assessment (conducted according to Annex I of REACH) indicates
that the Risk Characterisation Ratio is well below 1, and therefore the
risk is already adequately controlled and further testing is not
The silanol hydrolysis product,
3-aminopropylsilanetriol, upon which the chemical safety assessment is
based, is highly water soluble and has a low log Kow value, therefore
exposure of and accumulation in the sediment compartment is expected to
The substance is not adsorbing
(based on log Koc -0.6), has low bioavailability and low
potential for bioaccumulation (based on log Kow <3 (-4.0)),
low toxicity was observed in short- and long-term aquatic tests, and
there is no reason to expect any specific mechanism of toxicity beyond
narcosis. Therefore, the occurrence of more severe toxic effects in the
sediment compartment that were not expressed in the aquatic studies
would be considered unlikely.
The PNEC calculated by the
Equilibrium Partitioning Method has been determined for the purpose of
deriving a chemical safety assessment and the risk characterisation
ratios are below 1.
Overall it is concluded that the
risk characterisation conclusion is sufficiently conservative in respect
of any uncertainties and therefore further testing is not considered
Details on how the PNEC and the
risk characterisation ratio have been derived can be found in IUCLID
Section 6.0 and Chapters 9 and 10 of the Chemical Safety Report,
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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