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EC number: 246-467-6
CAS number: 24801-88-5
A GLP acute oral study was carried out in female Sprague-Dawley rats
exposed to triethoxy(3-isocyanatopropyl)silane by gavage, according to
OECD Test Guideline 423 (acute oral toxicity – acute toxic class method).
A group of three females was given a single oral gavage administration
of triethoxy(3-isocyanatopropyl)silane at 300 mg/kg bw (in arachis oil
BP) and observed for 14 days. No deaths or clinical signs were observed,
and no abnormalities were seen upon gross necropsy. The same results
were reported for another group of three females treated in the same way.
A further group was treated at a higher dose level of 2000 mg/kg bw
(undiluted). All three of the females treated by gavage at this dose
level died within four hours of dosing. Clinical effects (hunched
posture, ataxia, decreased breathing rate, diarrhoea, diuresis, lethargy
and pilo-erection) were noted in two of these animals. Abnormalities
seen at necropsy for these two animals included red lungs, dark liver
and kidneys, and slight haemorrhage of the gastric mucosa.
Triethoxy(3-isocyanatopropyl)silane was harmful to rats when given as a
single oral gavage administration at up to 2000 mg/kg bw. The LD50 value
was estimated to be in the range of 300 to 500 mg/kg bw.
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