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EC number: 246-467-6
CAS number: 24801-88-5
No effects were observed in Control or treated media.
96 hour LC50: >934
mg/l, mortality of Brachydanio rerio; equivalent to >579 mg/l as
3-aminopropylsilanetriol, read across from
3-aminopropyl(triethoxy)silane (CAS 919-30-2).
No data are available for the
The isocyanate group is very
rapidly hydrolysed to the corresponding amine (half-life <5 minutes at
pH 7), and further hydrolysis of the alkoxy groups proceeds at a slower
rate (half-life of 8.5 hours at pH 7 and 25°C).
Data are read across from
3-aminopropyl(triethoxy)silane (CAS 919-30-2), the amine which is formed
very rapidly when the registered substance comes into contact with water
A 96 hour LC50of >934
mg/l (measured DOC concentration) (highest concentration tested) has
been determined for the effects of 3-aminopropyl(triethoxy)silane (CAS
919-30-2) on mortality of Brachydanio rerio(tested as Danio
rerio), in accordance with OECD Test Guideline 203 and in compliance
with GLP (Hüls, 1994a).
The test substance is susceptible
to hydrolysis and, due to the test media preparation (stirring for 18
hours) and exposure regime (semi-static), it is likely that the test
organisms were predominantly exposed to the hydrolysis products of the
substance. Concentration measured by DOC is non-specific, therefore the
measured DOC concentration is likely to reflect the concentration of the
hydrolysis products, 3-aminopropylsilanetriol and ethanol.
Because the measured DOC
concentration is within 20 % of the nominal parent test substance
concentration of 1000 mg/l, the results may be expressed in terms of
concentration of the silanol hydrolysis product,
3-aminopropylsilanetriol, by applying a molecular weight correction: (MW
of silanol = 137.21 / MW of parent = 221.37) * >934 mg/l = >579 mg/l.
Both the registration
substance and the substance used as surrogate for read-across are
susceptible to hydrolysis reaction of the alkoxysilane groups (to
silanols) and to potential condensation reactions (described in Section
4.8 of IUCLID). During the tests with the read-across substance,
pre-hydrolysis and filtration were used as part of media preparation.
Analytical recoveries by DOC were high (within 20% of nominal). Models
would suggest that irreversible condensation is unlikely for these
silanol hydrolysis products at the concentrations relevant to the
studies (PFA, 2016am).
These findings are supported by a
96 hour LC50 in rainbow trout >100 mg/l, determined for
3-(trimethoxysilyl)propyl isocyanate (CAS 15396-00-6) (IBACON, 2003).
For this substance the isocyanate group is very rapidly hydrolysed to
the corresponding amine (half-life of minutes or less), and further
hydrolysis of the alkoxy groups proceeds at a slower rate (half-life of
2.6 hours at pH 7 and 20-25 °C, estimated) to 3-aminopropylsilanetriol
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