Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-131-3
CAS number: 7440-22-4
Read-across from the dissolved silver ion
is also applied to fulfil information requirements for uncoated and
coated nanosilver. Supporting information for this read-across is
included in endpoint summaries, in the appended nanosilver
summary/justification document, and in an appended summary of a
comparative testing programme undertaken for nanosilver and silver
Notter et al. (2014) presents a meta-analysis of published EC50
values for ionic silver and nanosilver. The authors demonstrate that
almost 94% of acute toxicity values assessed for freshwater, seawater
and terrestrial systems using algae, annelid, arthropoda, bacteria,
crustacea, fish, nematoda, plant, protozoa and rotatoria show that the
nanoform of silver is less toxic than the dissolved metal (when
normalised for total metal concentration). In addition, a specific
testing programme designed to compare the effects of nanosilver and
silver nitrate to algae, Daphnia (long-term) and soil
microorganisms (Schlich et al. 2017 a,b,c,d, and Smolders
andWillaert 2017) demonstrated that the nanoform of
silver is less toxic than ionic silver (based on EC10 and EC50 values
for total, ‘conventional’ dissolved (<0.45µm) and ‘truly’ dissolved
(<3kDa) silver). Therefore, taking the full body of evidence into
account, the read-across use of toxicity values from ionic to
nanosilver as a ‘worst case’ approach is justified and scientifically
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again