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EC number: 231-131-3
CAS number: 7440-22-4
Read-across from the dissolved silver ion
is also applied to fulfil information requirements for uncoated and
coated nanosilver. Supporting information for this read-across is
included in endpoint summaries, in the appended nanosilver
summary/justification document, and in an appended summary of a
comparative testing programme undertaken for nanosilver and silver
Notter et al. (2014) presents a meta-analysis of published
EC50 values for ionic silver and nanosilver. The authors demonstrate
that almost 94% of acute toxicity values assessed for freshwater,
seawater and terrestrial systems using algae, annelid, arthropoda,
bacteria, crustacea, fish, nematoda, plant, protozoa and rotatoria
show that the nanoform of silver is less toxic than the dissolved
metal (when normalised for total metal concentration). In addition,
a specific testing programme designed to compare the effects of the
smallest nanosilver form covered by the REACH dossier and silver
nitrate to algae, Daphnia (long-term) and soil microorganisms
(Schlich et al. 2017 a,b,c,d, and Smolders
and Willaert, 2017) demonstrated that the nanoform of
silver is less toxic than ionic silver (based on EC10 and EC50
values for total, ‘conventional’ dissolved (<0.45µm) and ‘truly’
dissolved (<3kDa) silver). Therefore, taking the full body of
evidence into account, the read-across use of toxicity values from
ionic to nanosilver as a ‘worst case’ approach is justified and
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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