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EC number: 231-131-3
CAS number: 7440-22-4
Table: mean percentage values of silver for Franz Diffusion Cell (% in respect to the initally applied amount)
The dermal absorption/percutaneous penetration of silver was determined in vitro (Bornatowicz, 2006). Silver was tested as micro-sized powder in a hydrophilic formulation at 0.5 and 1.5% Ag. The test substances was assessed via determination of Ag using ICP-MS.
Three integrity checked dermatomed skin preparations of one young pig were used in each experiment. Skins were inserted in static penetration cells (Franz-cells) with an application area of 1.0 cm².
The test substance formations were applied topically to the horny layer of the skin in nominal quantities of 20 mg/cm². A non-occlusive exposure under temperature controlled conditions was performed and formulations were left on the skin for 24h.
24h after application, the stratum corneum was removed by repeated stripping (absorbed test substance). The remaining skin was taken to determine absorbed test substance. Penetration was calculated via the mass of test substance in the receptor fluid. The amount of bioavailable test substance is defined as sum of absorbed + penetrated test substance.
Most of the test substance is wiped off at the end of exposure (60-67%). Tape stripping removed a large amount of test substance from the upper layers of the skin with the amount of silver decreasing with later strippings suggesting a low level of Ag in the deeper layers of the stratum 5%, absorption 1.38-2%). A very low amount of silver penetrates the skin (0.0007-0.0014%), with the amount of test item in the receptor fluid being below the Limit of Quantification for both formulations. The bioavailability of silver was calculated at 1.38-2.0%, corresponding to 1.52-6.54 µg/cm².
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