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EC number: 231-131-3
CAS number: 7440-22-4
ECHA guidance on aquatic bioaccumulation assessment for REACH
registration observes that it is not possible to make log Kow or
solubility based estimates of nanomaterial bioaccumulation as
nanomaterials within test systems are “dispersed” and not in solution.
As such, measured BCF values are required to fulfil data requirements
guidance also states that it is also of vital importance to consider
the influence of aggregation/agglomeration as well as dissolution on
bioaccumulation. If possible, information on bioaccumulation of
nanomaterials should be supported with information on the form of the
substance present in the animal tissue (i.e. are nanoparticles of
silver bioaccumulated or just ionic silver released from
et al. (2012) outline several problems with the performance of
conventional bioaccumulation tests using nanomaterials. Critically,
they question the founding assumption of the “steady-state” required
for BCF measurements from aqueous exposures as colloidal dispersions
(of nanomaterials) are dynamic systems which do not achieve steady
equilibrium state (Handy et al. 2008). Equally, uptake by endocytosis
(a potential mechanism of accumulation of nanoparticles) may also
confound the use of standard kinetic relationships employed in
bioaccumulation tests that are based on diffusion (i.e. the Fick
equations). Handy et al. (2012) warn against the application of
bioaccumulation tests without an appreciation of the underlying
mechanism of uptake and kinetics. Handy et al. (2012) also discuss the
use of diet borne studies. However, limited potential for the
verification of particle size distribution of nanomaterials when
incorporated into food (as per studies conducted in soils) are
considered to restrict the usefulness of diet-based bioaccumulation
tests with nanomaterials.
from the dissolved silver ion is also applied to fulfil information
requirements for silver and silver-based (coated) nanomaterials.
Supporting information for this read-across is summarised in endpoint
summaries and in further detail in the appended nanosilver read-across
RD, Henry TB, Scown TM, Johnstone BD, Tyler CR. 2008. Manufactured
nanomaterials: their uptake and effects on fish – a mechanistic
analysis. Ecotoxicology. 17: 396-409.
R, van den brink N, Chappell M, Mühling M, Behra R, Dušinská M,
Simpson P, Ahtiainen J, Jha AN, Seiter J, Bednar A, Kennedy A,
Fernandes TF, Riediker M. 2012. Practical considerations for
conducting ecotoxicity test methods with manufactured nanomaterials:
what have we learnt so far? Ecotoxicology. 21: 933-972.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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