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EC number: 229-722-6
CAS number: 6683-19-8
The substance was found to be not sensitizing in guinea pigs. The key
study was a guinea pig optimization test in which none of the 20 animals
showed skin reactions after the challenge reaction.
Table 1. Reaction volumes (μL) after intradermal injection of propylene
Table 2. Reaction volumes (μL) after intradermal injection of test
material (0.1 %).
Experimental data regarding skin sensitization is available from three
reports, all of them pre-dating GLP requirements. The key study was
chosen because it is the only one which is adequate in design and
reporting. Limitations are that positive control data not included in
the report and that the dose selection was not justified. The test is an
optimization test in guinea pigs performed with a suspension of 0.1% in
propylene glycol. As the test item is of overall solubility, the chosen
dose was probably the highest that could be injected. In 1980, another
study in guinea pig with a similar design was performed, however due to
the low number of animals, it is of limited value for hazard
assessment. A report on a human patch test with 50 volunteers is
available. No incidence of skin reactions was reported. Overall, the
substance is concluded to be non-sensitizing. Absence of findings in
animal studies is consistent with the very high molecular weight of 1178
Da of the test substance. Such substances are too large to penetrate the
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for
classification purposes under Regulation 1272/2008. As a result the
substance is not considered to be classified for skin sensitization
under Regulation (EC) No. 1272/2008.
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