Registration Dossier
Registration Dossier
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EC number: 229-722-6 | CAS number: 6683-19-8
Endpoint summary
Administrative data
Description of key information
No toxic effects have been observed in studies with soil living organisms.
Additional information
With an average maximum diameter of 25.5 Å (see IUCLID Chapter 5.3.1) , a molecular weight of 1180 g/mol and a log Kow of > 19.6 (according to ClogP3 and EPIwin calculations) the substance is considered to be not bioavailable and uptake of the substance in cells via membrane permeation of terrestrial organisms is unlikely. Especially for terrestrial organisms whose main exposure route to contaminants is pore water such as plants and microorganisms, uptake is not probable because of the high adsorption potential and poor water solubility of the substance. Due to the oral uptake of soil earthworms are the most suitable test organisms to determine the toxicity to soil organisms.
The effects on earthworm reproduction was investigated according to OECD guideline 222, with Eisenia fetida as test species[2019 ]. Up to the highest test concentration of 1000 mg/kg/dw (nominal) no adverse effects on biomass, reproduction, food consumption and morphology was observed. Hence, it can be concluded that the test substance is not harmful to earthworms.
No adverse effects in the solubility range were observed in acute and chronic aquatic toxicity studies and no hazard identified. Based on the available ecotoxicity data and the limited bioavailability due to the molecular size, no hazard is identified for soil organisms.
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