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EC number: 229-722-6 | CAS number: 6683-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In an in situ study on GI absorption the results indicate that only trace amounts, if any, of test material were absorbed in a 3-hour period. Based on physico-chemical properties and the hazard profile, the substance is not considered to be absorbed. There is no potential for bioaccumulation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Toxicokinetic assessment
The test substance (molecular weight > 1177 g/mol) is a white powder with a calculated Log Pow of 23, a water solubility of <0.1 mg/L at 20°C and a vapor pressure of 1.33 E-10 Pa at 20°C (estimated).
Absorption
Based on the physico-chemical data (low water solubility, molecule size, Log Pow) it is assumed that there is no or only very slow absorption after oral ingestion of the test article. This is supported by an old in situ absorption study. Here it could be shown that only trace amounts, if any, of test material were absorbed in a 3-hour period. In addition, the available acute oral toxicity studies did not reveal any signs of systemic toxicity and resulted in LD50 values of greater than 5000 mg/kg or higher. Furthermore, in the available 90-day feeding study with dogs using dose levels of 1000, 3000, 10000 ppm, no effects on body weight, food consumption, ophthalmology, clinical pathology, organ weights, and on histopathology were reported with a NOAEL of greater than 10000 ppm. In addition, a 2-year chronic feeding study with rats is available, which showed no findings of toxicological relevance up to the highest dose level of 10000 pm. The lack of systemic toxicity in these studies suggests poor bioavailability upon oral ingestion. In support of these findings are the results of an old absorption study performed with rat intestinal loops according to the Levine technique. This study showed that the test article was only absorbed in trace amounts, if at all, after a 3h exposure period. In addition, the diameter of the chemical was determined to be 17.9Å. According to a publication by Opperhuizen et al, a lipophilic particle with a diameter of greater than 9.5 Å has only limited ability to cross biological membranes (Opperhuizen et al, 1985). A second assessment found in ECHA Guidance on information requirements and chemical safety assessment, Chapter R.11, concludes that a substance is possibly not considered to be bioaccumulative if the average maximum diameter is greater than 17 Å and the molecular weight is larger than 1100. Based on this information, it can be assumed that the test article is not likely to cross biological membranes and has no bioaccumulation potential. Therefore, in line with all toxicological data available, systemic availability can be excluded.
Dermal absorption is equally unlikely, due to the size of the chemical, the Log Pow of 22 and the very low water solubility. Highly lipophilic substances that come into contact with the skin can readily penetrate the lipid rich stratum corneum but are not well absorbed systemically. Although they may persist in the stratum corneum, they will eventually be cleared as the stratum corneum is sloughed off. Furthermore, dermal uptake of chemicals with a molecular weight >500 is not favored (ECHA GD 7c). This is in line with the available toxicity data after dermal exposure. In an acute dermal toxicity study no indications of systemic availability after dermal application were detected. In conclusion, dermal penetration is expected to be very low.
In two inhalation toxicity studies, no effects were reported up to the highest doses tested. Given its low water solubility, systemic availability after exposure to dust particle of the test substance is expected to be low. In addition, particle size distribution analysis revealed a mass median diameter of 140.8 µm, therefore, the majority of generated particles will not penetrate into the broncho-alveolar tract.
Excretion
In view of the absence of relevant findings and the expected low bioavailability, it can be assumed that the test substance is rapidly excreted. Since the test substance has a molecular weight larger than 500 g/mol and a low solubility in water, it is expected to be excreted predominantly via the feces (ECHA GD 7c).
Overall conclusion
The physico-chemical data suggest that the test article cannot cross biological membranes and therefore absorption after oral, dermal and inhalative exposure is expected to be negligible. This is supported by the findings of available toxicity studies, which clearly demonstrated absence of systemic toxicity. The test article has not bioaccumulation potential and rapid excretion via the feces is expected.
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