Registration Dossier
Registration Dossier
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EC number: 229-722-6 | CAS number: 6683-19-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- Absorption study from intestinal loops
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: (R. M. Levine, M. R. Blair and B. B. Clark, J. Pharm. Exper. Ther., 114:78 (1955)
- Principles of method if other than guideline:
- Absorption study of from intestinal loops in rats (Levine technique) to determine the fraction of a chemical introduced into an intestinal loop in situ which is absorbed within a given period of time.
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
- EC Number:
- 229-722-6
- EC Name:
- Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
- Cas Number:
- 6683-19-8
- Molecular formula:
- C73H108O12
- IUPAC Name:
- 3-{[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}-2,2-bis({[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}methyl)propyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
- Details on test material:
- C14-labeled test material
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
Results and discussion
Any other information on results incl. tables
In experiments with 14C-labeled material, the amounts of test material recovered in control intestinal loops (zero time) and in experimental intestinal loops after a 3-hour absorption period were as follows:
| Control (Zero Time) | Experimental (3 hour) | |
| 710 | 675 | |
| 774 | 679 | |
| 778 | 685 | |
| 788 | 694 | |
| 823 | 730 | |
| 834 | 758 | |
| 802 | ||
| Mean ± S.D. | 784 ± 44 | 718 ± 48 |
The above figures indicate that only trace amounts, if any, of test material were absorbed in a 3 hour period.
Applicant's summary and conclusion
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