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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics, other
Remarks:
Absorption study from intestinal loops
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1966
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: (R. M. Levine, M. R. Blair and B. B. Clark, J. Pharm. Exper. Ther., 114:78 (1955)
Principles of method if other than guideline:
Absorption study of from intestinal loops in rats (Levine technique) to determine the fraction of a chemical introduced into an intestinal loop in situ which is absorbed within a given period of time.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
EC Number:
229-722-6
EC Name:
Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
Cas Number:
6683-19-8
Molecular formula:
C73H108O12
IUPAC Name:
3-{[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}-2,2-bis({[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}methyl)propyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate (non-preferred name)
Details on test material:
C14-labeled test material
Radiolabelling:
yes

Test animals

Species:
rat

Results and discussion

Any other information on results incl. tables

In experiments with 14C-labeled material, the amounts of test material recovered in control intestinal loops (zero time) and in experimental intestinal loops after a 3-hour absorption period were as follows:

Control (Zero Time) Experimental (3 hour)
710 675
774 679
778 685
788 694
823 730
834 758
802
Mean ± S.D. 784 ± 44 718 ± 48

The above figures indicate that only trace amounts, if any, of test material were absorbed in a 3 hour period.

Applicant's summary and conclusion