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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics, other
Remarks:
Absorption study from intestinal loops
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1966
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: (R. M. Levine, M. R. Blair and B. B. Clark, J. Pharm. Exper. Ther., 114:78 (1955)
Principles of method if other than guideline:
Absorption study of from intestinal loops in rats (Levine technique) to determine the fraction of a chemical introduced into an intestinal loop in situ which is absorbed within a given period of time.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
EC Number:
229-722-6
EC Name:
Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
Cas Number:
6683-19-8
Molecular formula:
C73H108O12
IUPAC Name:
3-{[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}-2,2-bis({[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}methyl)propyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
Details on test material:
C14-labeled test material
Radiolabelling:
yes

Test animals

Species:
rat

Results and discussion

Any other information on results incl. tables

In experiments with 14C-labeled material, the amounts of test material recovered in control intestinal loops (zero time) and in experimental intestinal loops after a 3-hour absorption period were as follows:

Control (Zero Time) Experimental (3 hour)
710 675
774 679
778 685
788 694
823 730
834 758
802
Mean ± S.D. 784 ± 44 718 ± 48

The above figures indicate that only trace amounts, if any, of test material were absorbed in a 3 hour period.

Applicant's summary and conclusion