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EC number: 229-722-6
CAS number: 6683-19-8
The test item was tested for skin and eye irritation in rabbits and was
found to be non-irritant. Upon occlusive application to skin for 24, no
indication of erythema and edema was observed during the observation
period of 3 days. Upon instillation of 100 mg into eyes, for non-rinsed
eyes, conjunctivae redness was observed at the 1h and 4h reading, but
not at later time points. Experimental data on respiratory irritation is
Table 1. Eye irritation response in rabbits treated with test materiala
a) Two rabbits per wash condition.
b) Maximum cornea response = 80; maximum iris response = 10; maximum
conjunctivae response = 20.
The key studies for skin and eye irritation were performed prior to the
introduction of GLP but are reported in adequate detail and followed a
procedure that allowed for classification and labelling. The test design
of the eye irritation study is comparable to that of OECD testing
guideline 405 whereas that of the skin irritation is more stringent than
that of OECD testing guideline 404. The tests were performed with a
commercial product. The results are consistent with the findings of an
older study that was also performed with a commercial sample.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for
classification purposes under Regulation 1272/2008. As a result the
substance is not considered to be classified for skin or eye irritation
under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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