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EC number: 476-160-4
CAS number: 54807-34-0
Table 1. Effects of DMH oral doses at
2000, 6000 and 20000 ppm, to parental and offspring F1 and F2
reproductive performance and pup survival indice
F0 at F1 breed
Mating index (%)
Fertility index (%)
Gestational length (days)
Fecundity index (%)
Gestation index (%)
Pup survival indices
Live birth index
28 day survival index
F1 at F2 breed
Live birth index (%)
Lactation index (%)
28 day survival index (%)
This study has been performed on DMH (Dimethyl Hydantoin)
and has been used for read-across purposes.
In conclusion, continuous exposure to DMH in
the diet for two generations did not result in parental toxicity or
adverse effects on reproduction or reproductive tissues at dietary
concentrations as high as 20000 ppm. Small increases in parental food
consumption and body weight and slight transient decreases in offspring
body weight were observed at the 20000 ppm dose level. The
no-observed-effect level (NOEL) for parental animals and offspring in
this study was 6000 ppm. The NOEL for reproductive effects was at least
20000 ppm. The substance DMH is not a reproductive toxin in this study
but there may be an effect on lactation.
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