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EC number: 476-160-4
CAS number: 54807-34-0
A study was not carried out on the chemical NaDMH, three studies were however carried out on the analogue chemical DMH and are to be considered for the purposes of read-across.The studies provided show that DMH was steadily degraded at 20 °C in the absence of light giving whole system and aqueous phase DT50 values of 13 to 24 days and DT90 values of 42 to 79 days. After 17 weeks, 65% of initial radioactivity was mineralised to CO2.
The key study has been performed to an
appropriate guideline under GLP in an artificial water/sediment system
and a natural system for a period of 120 days. DMH is a polar molecule
and was expected to be retained mainly in the surface water phase and be
exposed to predominently aerobic conditions. The fastest degradation
rates were observed in the water rather than the whole system. 90 %
degradation of DMH was observed after 42 to 79 days in the two
water/sediment systems with more rapid degradation in the natural system
. 50 % degradation of DMH was observed after 13 to 24 days for both
systems. The most environmentally relevant half life in water was 12.7
days in the natural water.
There are two supporting studies for aerobic
and anaerobic degradation performed to old EPA guidelines which have
been superseded by OECD 308. Both studies were performed on a single
sediment type and the study methods have clearly defined limitations.
The Schmidt & Stansbrey study indicated the formation of at least two
unidentified degradation products under anaerobic conditions after one
year. In the aerobic study (Schmidt,1993) only a small amount of DMH
mineralisation to CO2 (<6% of initial measured dose) after one year
under aerobic conditions.
As previously stated these studies have been
performed on DMH (Dimethyl Hydantoin) and have been used for read-across
purposes. A summary of data for read-across of NaDMH with DMH is given
in Section 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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