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EC number: 476-160-4
CAS number: 54807-34-0
hydrolysis study has been performed on DMH (Dimethyl Hydantoin)
and has been used for read-across purposes. The results of the study
demonstrated that DMH was not hydrolyzed in aqueous media at a pH of 5
and 9. At a pH of 7 hydrolysis of DMH was minimal, resulting in very
long half-lives. At pH 7, half-life is 3194 days in TRIS Buffer at 25°C
and at pH 7 in HEPES Buffer 1715 days.
A readily biodegradability test in
accordance with GLP and OECD Guideline 301 B was performed on the
chemical NaDMH. NaDMH attained 85% degradation after 28 days and is
therefore considered readily biodegradable. Additionally a read-across
study on the analogue chemical DMH attained 88% degradation after 28
days and this also was considered readily biodegradable.
Biodegradation in water and sediment:
A biodegradation study in water and sediment
was not carried out on the chemical NaDMH, three studies were however
carried out on the analogue chemical DMH and are to be considered for
the purposes of read-across. The studies provided show that DMH was
steadily degraded at 20 °C in the absence of light giving whole system
and aqueous phase DT50 values of 13 to 24 days and DT90 values of 42 to
79 days. After 17 weeks, 65% of initial radioactivity was mineralised to
According to Annex IX section 188.8.131.52 of
Regulation No. 1907/2006 “Further biotic degradation testing shall be
proposed by the registrant if the chemical safety assessment according
to Annex I indicated the need to investigate further the degradation of
the substance and its degradation products”. Adequate information on the
degradation of DMH is available which shows that it is readily
biodegradable and therefore no further testing for this endpoint is
bioaccumulation study has been performed on DMH (Dimethyl Hydantoin)
and has been used for read-across purposes. Concentrations of
radioactivity in edible and non-edible tissues of bluegill exposed to
14C-DMH at 1.0 ppm were lower than the limit of quantitation therefore
DMH did not bioconcentrate in fish tissue (BCF < 1.79).
The adsorption/desorption study has been
performed on DMH (Dimethyl Hydantoin) and has been used for read-across
purposes. Based on the range of Koc values DMH (Koc >23.4 - <147; logKoc
>1.37 - <2.17) was considered as having a high mobility in soil.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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