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Environmental fate & pathways

Hydrolysis

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Description of key information

The hydrolysis study has been performed on DMH (Dimethyl Hydantoin) and has been used for read-across purposes. The results of the study demonstrated that DMH was not hydrolyzed in aqueous media at a pH of 5 and 9. At a pH of 7 hydrolysis of DMH was minimal, resulting in very long half-lives. At pH 7, half-life is 3194 d in TRIS Buffer at 25°C and at pH 7 in HEPES Buffer 1715 d.

Key value for chemical safety assessment

Additional information

The hydrolysis study has been performed on DMH (Dimethyl Hydantoin) and has been used for read-across purposes.

The parent compound did not significantly hydrolyze in the pH range 5-9 as determined by thin layer and high performance liquid chromatography. The half-life of DMH was greater than 1700 days at pH7. Half-lives were not
calculated for pH5 and pH9 systems as positive slopes were obtained based on the linear regression analysis of the
data.