Registration Dossier
Registration Dossier
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EC number: 407-420-7 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The level of accumulation (BAF) of test substance in carp was all below 1.6 times at Test level 1, and also below 15 times at Test level 2. In order to trace the minor components other than six selected, the sensitivity was increased 5 times to confirm these accumulations. This analysis showed no such components accumulated in fish.
Key value for chemical safety assessment
Additional information
The study was conducted to study the bioaccumulation of test substance in the tissues of the carp in according to OECD Guideline 305 C and "Bioaccumulation test of chemical substances in fish body" laid down in "the Test requirement on New chemical substances" (KNHOGYO No.5, YAKUHATSU No.615, 49-KIKYOKU NO.392 dated on 13 Jul 1974).
Carps were exposed to nominal levels of 4.31 (Test level 1) and 0.431 (Test level 2) mg/L of test substance in test water using continuous flow-through diluter system (1000 L/day) for 8 wk. HPLC method was used for the analysis of test substance in test media and test fish. The concentration of test substance in test water has been kept constantly at the nominal levels
Prior to bioaccumulation test, a 48 acute toxicity test with Japanese rise fish was conducted in accordance with the OECD Guideline 203 under semi-static conditions to confirm the nominal concentrations of the bioaccumulation test were less than a hundredth and thousandth of 48 h LC50. The 48 -h LC50 was calculated on the basis of nominal concentrations. The 48-h LC50 of the test substance was > 431 mg/L.
The level of accumulation (BCF) of test substance in carp was all below 1.6 times at Test level 1, and also below 15 times at Test level 2. In order to trace the minor components other than six selected, the sensitivity was increased 5 times to confirm these accumulations. This analysis showed no such components accumulated in fish (Matsunobu N, 1993).
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