Registration Dossier
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EC number: 407-420-7 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The hydrolysis of the test substance was studied at pH 4, 7 and 9 in hydrolysis as a function of pH test conducted according to EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH).
Kobs 8.22 x 10 -2 /day at pH 4 50 deg C and the half-life was 8.43 days at pH 4 50 deg C
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 8.43 d
- at the temperature of:
- 50 °C
Additional information
The hydrolysis of the test substance was studied at pH 4, 7 and 9 in hydrolysis as a function of pH test conducted according to EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH).
The hydrolysis of the test substance was studied at pH's 4, 7 and 9. Solutions of Hl12323 were prepared in buffer solutions and these were
stored in amber coloured flasks at 50oC. The concentration of the main component of Hl12323 was monitored over several days by high performance liquid chromatography (HPLC). Duplicate tests were carried out at each pH.
For both pH 7.0 and 9.0 there was less than 10% hydrolysis of the test substance. For the pH 4.0 experiment an overall hydrolysis of around 30% was obtained. Using the above data obtained at pH 4.0 a graph was plotted of the mean of log concentration versus time to calculate the rate constant. As a linear plot was obtained the reaction is pseudo-first order. From the graph, the following parameters could be calculated:
Kobs 8.22 x 10-2/day at pH 4 and 50°C and the half-life was 8.43 days at pH 4 and 50°C
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