Registration Dossier
Registration Dossier
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EC number: 271-603-6 | CAS number: 68586-02-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Identification of contact allergens: the mouse ear sensitization assay
- Author:
- Descotes, J
- Year:
- 1 988
- Bibliographic source:
- J Toxicol -Cut & Ocular Toxicol 7:263-272
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Mouse ear swelling test. Substance applied to mouse ear with adjuvant with measure of subsequent swelling used to indicate hypersensitivity.
- GLP compliance:
- not specified
- Type of study:
- mouse ear swelling test
Test material
- Reference substance name:
- Ethanol
- EC Number:
- 200-578-6
- EC Name:
- Ethanol
- Cas Number:
- 64-17-5
- Molecular formula:
- C2H6O
- IUPAC Name:
- ethanol
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
Study design: in vivo (LLNA)
- Vehicle:
- unchanged (no vehicle)
- No. of animals per dose:
- 10
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Key result
- Parameter:
- other: ear swelling
- Value:
- ca. 26.94
- Variability:
- 1.02
- Test group / Remarks:
- male
- Key result
- Parameter:
- other: ear swelling
- Value:
- ca. 24.3
- Variability:
- 1.38
- Test group / Remarks:
- female
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An ear swelling study was used to examine the skin sensitising potential of ethanol. Ethanol was concluded as not sensitizing under conditions of this study.
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