Ethoxybis(pentane-2,4-dionato-O,O')(propan-2-olato)titanium

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Reference 1

Endpoint:

acute toxicity: oral

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

According to hydrolysis test results, the hydrolysis rate is estimated to be within 30 minutes. The hydrolysis products have been identified to be ethanol, 2-propanol, acetylacetone and titanium dioxide.
The properties of the target substance would lie in the hydrolysis products.

Reference 2

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Justification for type of information:

2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Species:

rat

Strain:

Wistar

Sex:

male/female

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

1, 0.71, 0.50, 0.25 ml/kg bw

No. of animals per sex per dose:

5

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 760 mg/kg bw

95% CL:

>= 655 - <= 890

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

ca. 570 mg/kg bw

95% CL:

>= 485 - <= 675

Clinical signs:

sluggishness, tremors, kyphosis, lacrimation, unsteady gait, comatose appearance and prostration.

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LD50 value tested on rat was 570 / 760 mg/kg bw in female/male. The substance was classified as category 4 according to GHS.

Executive summary:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Reference 3

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

2-propanol is the main hydrolysis prodcuts of the target substance. Properties of the the hydrolysis substance are used for read-across.

Qualifier:

no guideline available

Principles of method if other than guideline:

Handbook review value.

GLP compliance:

not specified

Test type:

acute toxic class method

Limit test:

no

Species:

rat

Strain:

not specified

Sex:

not specified

Route of administration:

oral: unspecified

Vehicle:

not specified

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 5 800 mg/kg bw

Based on:

test mat.

Interpretation of results:

GHS criteria not met

Conclusions:

LD50 rat of 2-propanol is 5800 mg/kg bw according to reported value. Pratically non-toxic according to GHS criteria.

Executive summary:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

570 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Reference 1

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

According to hydrolysis test results, the hydrolysis rate is estimated to be within 30 minutes. The hydrolysis products have been identified to be ethanol, 2-propanol, acetylacetone and titanium dioxide.
The properties of the target substance would lie in the hydrolysis products.

Reference 2

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Justification for type of information:

2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

traditional method

Species:

rat

Strain:

Wistar

Sex:

male/female

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Duration of exposure:

ca. 4 h

Concentrations:

628, 919, 1231, 1508 ppm

No. of animals per sex per dose:

10

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

ca. 1 224 ppm

Based on:

test mat.

Clinical signs:

other: Blepharospasm, lacrimation, abdominal breathing, urogenital wetness, decreased activity, encrustation around eyes and nose

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

4hr LC50 tested on rat was 1224 ppm (5.1 mg/l) and the subsatnce therefore was classified as catagory 3 according to GHS.

Executive summary:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Reference 3

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

according to guideline

Guideline:

other: US EPA TSCA guidelines for neurotoxicity

GLP compliance:

not specified

Test type:

acute toxic class method

Limit test:

no

Species:

rat

Strain:

Fischer 344

Sex:

male/female

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

not specified

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

ca. 6 h

Concentrations:

500, 1500, 5000, 10000 ppm

No. of animals per sex per dose:

25

Control animals:

yes

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 10 000 ppm

Based on:

test mat.

Exp. duration:

6 h

Sex:

male/female

Dose descriptor:

other: sedation of central nervous system

Effect level:

ca. 5 000 ppm

Based on:

test mat.

Exp. duration:

6 h

Sex:

male/female

Dose descriptor:

other: decrease in motor activity

Effect level:

ca. 5 000 ppm

Based on:

test mat.

Exp. duration:

6 h

Mortality:

No mortality

Interpretation of results:

GHS criteria not met

Conclusions:

6h LC50 tested on rat was > 100000 ppm (> 24600 mg/m3)

Executive summary:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LC50

Value:

5 006 mg/m³

Acute toxicity: via dermal route

Link to relevant study records

Reference

Reference 1

Endpoint:

acute toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

According to hydrolysis test results, the hydrolysis rate is estimated to be within 30 minutes. The hydrolysis products have been identified to be ethanol, 2-propanol, acetylacetone and titanium dioxide.
The properties of the target substance would lie in the hydrolysis products.

Reference 2

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Justification for type of information:

2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hr

Doses:

0.5, 1, 2 ml/kg bw

No. of animals per sex per dose:

5

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

ca. 790 mg/kg bw

Based on:

test mat.

95% CL:

>= 560 - <= 980

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 1 370 mg/kg bw

Based on:

test mat.

95% CL:

>= 770 - <= 2 100

Mortality:

death occurred within 1-24 h after application

Clinical signs:

Red mottled lungs and congestion of the tracheal mucosa were observable. Local effects comprised erythema, edema, scab formation and necrosis.

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

Acute dermal toxicity was tested using rabbit according to OECD guudeline 402. The LD50 values were 790 and 1370 for femal and male rabbits respectively. The lower value was chosen as the key result and the substance was classified as category 3 according to GHS.

Executive summary:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Reference 3

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Qualifier:

no guideline available

Principles of method if other than guideline:

Data obtained from peer-reviewed source.

GLP compliance:

not specified

Test type:

fixed dose procedure

Limit test:

no

Species:

rabbit

Strain:

not specified

Sex:

not specified

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 12 870 mg/kg bw

Based on:

test mat.

Interpretation of results:

GHS criteria not met

Conclusions:

The dermal LD50 on rabbits was greater than 12870 mg/kg bw, pratically non-toxic according ly GHS criteria.

Executive summary:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

790 mg/kg bw

Additional information

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

 

The acute toxicity of pentane-2,4-dione was investigated by the oral, dermal and inhalation route, respectively. By either route of administration the material proved to be moderately toxic to the animals tested. The oral LD50 in rats was 570 and 760 mg/kg bw, female and male respectively. The dermal LD50 in rabbits, applied to shaved skin, was 790 and 1370 mg/kg bw for female and male. The inhalation LC50 (4h) in Wistar rats was 1224 ppm, female and male. (Ballantyne B. et al., 1986)

 

TiO2 was considered non-hazardous, based on the published data on EHCA C&L database. The lowest dose reported to produce any toxic effect in rats by oral route is determined to be 60 g/kg (US EPA, 1994).

 

The most hazardous hydrolysis product – pentane-2,4-dione – was therefore used for CSA evaluation.

Justification for classification or non-classification

The oral LD50, inhalation LC50 and dermal LD50 read-across from pentane-2,4-dione are 570 mg/kg bw, 5006 mg/m3 and 790 mg/kg bw respectively.

As the intrinsic properties of the target substance are related to the decomposition products, this target substance is classified for hazard class
Acute toxicity oral 4, H302

Acute toxicity dermal 3, H311

Acute toxicity inhalation 3, H331
according to CLP Regulation 1272/2008.