Registration Dossier
Registration Dossier
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EC number: 271-603-6 | CAS number: 68586-02-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- 2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.
Data source
Reference
- Reference Type:
- publication
- Title:
- The acute toxicity and primary irritancy of 2,4-pentanedione
- Author:
- Ballantyne B, Dodd DE, Myers RC, Nachreiner JJ
- Year:
- 1 986
- Bibliographic source:
- Drug Chem. Toxicol. 9: 133-146
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- Pentane-2,4-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1, 0.71, 0.50, 0.25 ml/kg bw
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 760 mg/kg bw
- 95% CL:
- >= 655 - <= 890
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 570 mg/kg bw
- 95% CL:
- >= 485 - <= 675
- Clinical signs:
- sluggishness, tremors, kyphosis, lacrimation, unsteady gait, comatose appearance and prostration.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 value tested on rat was 570 / 760 mg/kg bw in female/male. The substance was classified as category 4 according to GHS.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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