Registration Dossier
Registration Dossier
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EC number: 271-603-6 | CAS number: 68586-02-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- 2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.
Data source
Reference
- Reference Type:
- publication
- Title:
- The acute toxicity and primary irritancy of 2,4-pentanedione
- Author:
- Ballantyne B, Dodd DE, Myers RC, Nachreiner JJ
- Year:
- 1 986
- Bibliographic source:
- Drug Chem. Toxicol. 9: 133-146
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- Pentane-2,4-dione
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hr
- Doses:
- 0.5, 1, 2 ml/kg bw
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 790 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 560 - <= 980
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 370 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 770 - <= 2 100
- Mortality:
- death occurred within 1-24 h after application
- Clinical signs:
- Red mottled lungs and congestion of the tracheal mucosa were observable. Local effects comprised erythema, edema, scab formation and necrosis.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Acute dermal toxicity was tested using rabbit according to OECD guudeline 402. The LD50 values were 790 and 1370 for femal and male rabbits respectively. The lower value was chosen as the key result and the substance was classified as category 3 according to GHS.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
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